Osteoporosis is one of the common diseases. Due to the serious complications, which cause disabilities and significant deterioration of the quality of life, it also presents a large public health problem, as well as a financial burden for the patients, their families, and the whole of society. The common clinical practice widely applied for >20 years has been based on the paradigm introduced on the hypothesis that osteoporosis is the consequence of decreasing bone mass due to increasing bone reabsorption over bone formation which makes bone prone to fractures. Based on that, bone densitometry has been introduced as a “golden” diagnostic standard and pharmacotherapy, with the goal of reducing bone reabsorption, has been introduced as a standard treatment. However, despite various drugs, the problem of osteoporosis is not solved or decreased. Also, complications such as drug adverse events and fractures after long-term pharmacotherapy presents a serious problem. Additionally, recent scientific research showed that osteoporosis is much more complex than was thought. So, clinical experience as well as scientific evidence clearly indicate the need for a significant change in clinical approach by introducing a new paradigm. According to the fact that osteoporosis is caused by the deterioration of bone matrix and bone architecture under the influence of various genetic, biomechanical, and biochemical factors, the new paradigm needs to be based on the principles of personalized and integrative medicine with the goal of improving biomechanical and metabolic balance, with stimulation of bone and cartilage regeneration, and thus improvement of the functional capacity of the musculoskeletal organ as a whole.
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