COVID-19 pandemic, apart from the death toll and destroyed economies, has changed the world in a previously unseen way of great magnitude. The development of vaccines has not achieved the expected effect in the fight against this virus for complex reasons. Poor communication, economic, political, and religious interests are colliding daily. This fact may certainly influence COVID-19 vaccine hesitancy. Scientists possess all the rights and obligations to coordinate concrete societal actions and promote a positive attitude toward vaccination. Implementation of other measures should be updated and carried out only on the bases of the scientific truth. This may be, so far, the only way to conquer the invisible and disastrous enemy of humankind.